Below is a statement from Global HIV Vaccine Enterprise executive director, Dr. Alan Bernstein.  The Enterprise (http://www.hivvaccineenterprise.org) is a global alliance of researchers, funders, policy makers and advocates that includes the African AIDS Vaccine Program, the AIDS Vaccine Advocacy Coalition (AVAC), the AIDS Vaccine Asian Network, the Bill & Melinda Gates Foundation, the Canadian HIV Vaccine Initiative, the Center for HIV/AIDS Vaccine Immunology, the Chinese AIDS Vaccine Initiative, the Collaboration for AIDS Vaccine Discovery (CAVD), the Department for International Development, the European Commission, Europrise, Eurovacc, GlaxoSmithKline, the HIV Vaccine Trials Network (HVTN), the International AIDS Vaccine Initiative (IAVI), Merck & Co. Inc., the National Agency for AIDS Research (ANRS), the National Institute of Allergy and Infectious Diseases (NIAID), Novartis Vaccines, sanofi pasteur, the South African AIDS Vaccine Initiative (SAAVI), the U.S. Military HIV Research Program (MHRP), UNAIDS, USAID, Vaccine Research Center (VRC), Wellcome Trust and the World Health Organization (WHO).

Dr. Bernstein is available to speak with journalists to help put the Thai trial results into perspective and to comment on their significance for the future of HIV vaccine research.  To interview Dr. Bernstein, please contact Mark Aurigemma at (212) 600-1960, (646) 270-9451 or mark@aucomm.net; or Jennifer Brunet at (212) 46i-3693 or jbrunet@vaccineenterprise.org.

“This is a historic day in the 26-year quest to develop an AIDS vaccine.  The results of the Thai Phase III HIV vaccine clinical trial of the “prime-boost” combination of ALVAC-HIV vaccine and AIDSVAC B/E vaccine demonstrate that a safe and effective AIDS vaccine is an achievable goal. This trial is the first demonstration in humans that, with more research, it will be possible to develop a vaccine that is fully protective against HIV.

These results represent the most significant advance in HIV vaccine research to date, and a ray of hope for the more than 2.7 million women, men and children who become newly infected with HIV every year across the globe.  Current prevention efforts can lower HIV risk, but a safe and effective vaccine will be essential to ending this epidemic.

We owe an enormous debt of thanks to the people of Thailand, and especially to the more than 16,000 women and men who selflessly participated in this clinical trial. This significant scientific milestone – the first vaccine study to reduce HIV infections in humans – would not have been reached without their engagement and the efforts of the trial sponsors – Enterprise stakeholders including the U.S. Military HIV Research Program (MHRP), the U.S. National Institute of Allergy and Infectious Diseases (NIAID), and sanofi pasteur – as well as the Thailand Ministry of Public Health and Global Solutions for Infectious Diseases (GSID).

The reduction in HIV infection risk measured in this study, 31.2 percent, was modest, but raises important implications for future research directions. HIV vaccine researchers, funders and advocates must now continue to work together, as quickly and effectively as possible, to understand why this vaccine regimen worked as it did, how its efficacy can be improved, whether and how it may work in other parts of the world, and how to develop new vaccine candidates that expand on the level of protection achieved here.

This study also demonstrates the importance of global cooperation and collaboration – the central values of the Global HIV Vaccine Enterprise – in accelerating the search for a safe and effective HIV vaccine.  Researchers, advocates, funders and policy makers are working together through the Global HIV Vaccine Enterprise process to develop and test new vaccine candidates. Full data from the Thai trial will be presented at the Enterprise’s annual scientific conference, AIDS Vaccine 2009, in Paris on October 19-22. http://www.hivvaccineenterprise.org/conference/2009/

Finally, these results are an immediate call to action to governments, funders, policy makers, researchers and advocates to dramatically step up our efforts to develop and make globally available a safe and effective HIV vaccine. Stakeholders of the Global HIV Vaccine Enterprise will continue to lead this fight, but developing a safe and effective AIDS vaccine will require the full and collective efforts of every individual and organization worldwide committed to ending this devastating epidemic.

Global HIV Vaccine Enterprise partners will be working aggressively in the months ahead to address the many scientific questions raised by this study, and to develop and test other vaccine candidates.  The findings of this trial will also help inform strategies outlined in the updated Enterprise Scientific Strategic Plan, the global strategy for HIV vaccine research currently being developed by over 150 scientists from around the world, to be released in spring 2010.

We look forward to hosting the ongoing discussion of results of this trial and the discussion of next steps in the journey to find an AIDS vaccine at the AIDS Vaccine 2009 conference in Paris, October 19-22.

On May 11, 2009 the Lukiiko (National Assembly) of Buganda sat to discuss a draft of the proposed new land law from Mr. Museveni’s government. Below the Luganda press release by the Buganda minister of Lukiiko Affairs and Information, followed by an English translation (by Buganda Post).

Reaction to the resolutions by ordinary Baganda have been mixed. On one extreme are the polititicaly aware men and women who are not afraid of President Museveni and are frustrated by, what they claim to be the cowardice reflected in the resolution. One of these is one Kampala businessman who said: “It is a shame that while our forefathers and Muteesa II died for Buganda, today’s Lukiiko is even afraid of making Museveni angry by stopping to beg him for our stolen property”. And on the opposite side are those who insist that if we carefully and respectfully tell Mr. Museveni what Buganda wants, he will one day be kind and give everything back to us. This group includes Uganda prime minister Apollo Nsibambi, Vice President Gilbert Bukenya and other staunch supporters Katikkiro JB Walusimbi and Buganda minister Charles Peter Mayiga.

EBITEESO EBIYISIDDWA OLUKIIKO LWA BUGANDA – May 11, 2009

Olukiiko lwa Buganda olutudde olwaleero nga 11 May 2009, lutegedde bulungi ya Ssabawolereza wa Gavumenti ya Ssaabasajja Kabaka ku bbago ly’enkola y’enfuga y’ettaka mu Uganda.  Oluvanyuma lw’okukubaganya ebirowoozo ebiteeso bino wamanga biyisiddwa:

1.   Newankubadde nga waliwo ensonga enkulu ezirambikiddwa mu bbago ly’enkola n’enkozesa y’ettaka eryakasembayo okufuluma, naye wakyaliwo ensonga endala enkulu ennyo eziruma Buganda ez’etaaga okwekenenya n’okukenenula n’obwegendereza nga tetunatuuka ku nzikiriziganya ey’awaamu ku nkola y’enfuga y’ettaka mu Uganda.

2.   Wakyaliwo ettaka lya Buganda lingi erikyali mu mikono gya Gavumenti eyawakati eryanyagibwa nga kyandibadde kirungi Buganda okuwa ebirowoozo ku nkola en’efuga ettaka mu Uganda, ng’ettaka eryo limaze okukomezebwawo eri bannyini lyo abatuufu nga mwemuli n’ettaka lya lukale mu Buganda erimanyiddwa nga erya Mayiro 9000, embuga z’amasaza, amagombolola emiruka n’Ebyaffe bonna omuli ne official Estates.

3.   Olukiiko lusabye Katikkiro wa Buganda ategeeze Gavumenti eya wakati eyamuwereza ebbago ly’enfuga eyo agitegeeze ebiteeso by’olukiiko bino wamu n’ensonga zonna ezirambikiddwa mu kiwandiiko kya Ssaabawolereza wa Gavumneti ya Buganda.

CHARLES PETER MAYIGA
MINISITA W’ENSONGA Z’OLUKIIKO N’AMAWULIRE

RESOLUTIONS OF THE BUGANDA LUKIIKO – MAY 11, 2009

The Buganda Lukiiko which has sat today on May 11, 2009, has fully understood the presentation by the Attorney General of Ssaabasajja Kabaka’s Government on the draft new law intended to govern land administration in Uganda. After discussion, it has been resolved as follows:

1.  Although  there are many important questions which have been addressed in the latest draft of the proposed law, many important issues that negatively affect Buganda remain, which require careful further study and analysis before we can reach comprehensive agreement on how land administration should work in Uganda.

2.  The [Uganda] central government still holds a lot of land that was stolen from Buganda and it would be nice for Buganda to participate in the debate on the law after that land has been returned to its rightful owners, and that includes the 9,000 square miles of [Buganda] native lands, real estate for ssaza (county), ggombolola (sub-county) and miruka (parish) headquarters and all that is ours (“Ebyaffe”), including office estates.

3. The Lukiiko has requested the Katikkiro of Buganda to communicate these resolutions to the [Uganda] central government which sent the draft proposed land law, along with the additional details which have been documented by the Attorney General of the Buganda Government.

CHARLES PETER MAYIGA
MINISITA W’ENSONGA Z’OLUKIIKO N’AMAWULIRE